Take "Amoxiclav" before meals or after?
The antioxidant amoxicillin along with potassium salt, which acts as an inhibitor of enzymes, is included in the composition of the medical product "Amoksiklav". This drug belongs to the pharmacological category of penicillins. And about whether to take "Amoxiclav" before or after meals, we'll talk further in the article.
Drug release form
The drug is released in the form of tablets that are coated as well as in the form of a powder for suspensions and injections. One tablet contains 250 milligrams of amoxicillin. Also, one tablet contains 120 milligrams of clavulanic acid. Auxiliary components here are the following substances:
- sodium salt;
- magnesium stearate;
- hypromellose with ethyl cellulose;
- titanium dioxide;
- triethyl citrate.
Tablets are supplied in bottles, 15 pieces each. One box contains one bottle of this medicine. Powder for suspension is also produced in vials. For injection use lyophilized powder. The content of amoxicillin in the solution is 500 mg.In turn, the amount of potassium salt is 100 mg.
Now let's find out how to take Amoxiclav properly - before or after meals.
Pharmacological action of the drug
The combination of substances such as amoxicillin with clavulanic acid is unique in its nature. Amoxicillin along with other antibiotics from the penicillin category can cause bacterial cell death by binding surface receptors. However, the majority of bacteria during the use of this tool have learned to destroy the antibiotic with the help of an enzyme called beta-lactamase.
Clavulanic acid significantly reduces the activity of this enzyme, thanks to which the Amoxiclav preparation is characterized by a wide spectrum of action. Before a meal or after it is consumed, it is advisable to find out in advance what we will do later in the article.
The said remedy even kills strains of bacteria that have managed to develop resistance to amoxicillin, and has a pronounced bacteriostatic and bactericidal effect on all types of streptococci. True, there are some exceptions that make up methicillin-resistant strains in the form of echinococci, and, in addition, Listeria.
Gram-negative bacteria are sensitive to “Amoxiclav” (to give the child before or after meals, we'll find out a little later). These include:
- Clostridium and others.
Regardless of whether "Amoxiclav" was taken before meals or after it, it is perfectly absorbed into the blood, and its maximum concentration can be established already in the first hour after consumption. "Amoxiclav" has a high distribution rate in the body. First of all it concerns the lungs, synovial fluid, tonsils, prostate gland, adipose tissue and sinuses.
In the tissues, the highest level of the drug is observed one hour after the maximum concentration in the blood plasma. The medicine is usually in small quantities in breast milk.
It should be noted that amoxicillin undergoes some destruction in the body. As for clavulanic acid, it is metabolized rather intensively. Displays medication by the kidneys. An insignificant process of elimination is carried out through the lungs and intestines
The elimination period for healthy kidneys ranges from one to one and a half hours.
Indications for use
This antibiotic is prescribed for the treatment of various infectious diseases. These include:
- Diseases of the respiratory tract in the form of acute or chronic sinusitis.
- Inflammations of the middle ear, along with the pharyngeal abscess, bronchitis, tonsillofaringitis, pneumonia, etc.
- Diseases of the urinary tract, which manifest in the form of cystitis, pyelonephritis, urethritis, etc.
- Gynecological infections along with endometritis, septic abortion, salpingitis.
- Inflammation of the biliary tract, for example cholangitis and cholecystitis.
- Infections of connective and bone tissues.
- Infections that occur in soft tissues and skin. As an example in this situation, various bites, cellulitis and wound infections can be given.
- Genital infections, such as chancroid or gonorrhea.
- The presence of odontogenic infections, in which the pathogen enters the body through the dental cavity.
So, we find out before the meal or after "Amoxiclav" is most effective.
Instructions for use
Doctors prescribe this remedy in different ways.The method of administration depends on factors such as the age of the patient, his weight, the severity of the infection and the condition of the kidneys and liver. The best time to take the drug is the beginning of the use of food. The course of taking this drug is usually from 5 to 14 days. Longer than this period can not be used.
And how is “Amoxiclav” prescribed to children - before meals or after meals? As a rule, doctors advise to use it with food. For children under 12 years old, use 40 mg of the drug per kilogram of weight. For children whose weight exceeds 40 kg, the drug is prescribed, as well as adults.
Adult pills should be taken every eight hours during the day. When prescribing this drug for the treatment of especially severe infections, doses of 625 mg are used every eight hours.
It should be noted that the drug may differ in the proportions of the active components. Therefore, it is forbidden to replace a pill of 625 mg with two 375 each.
For the treatment of odontogenic infections using the following scheme:
- 375 mg tablets are taken every eight hours during the day.
- A tablet of 625 mg - every twelve hours.
If you need to use this drug in order to treat patients suffering from kidney disease, it is imperative to consider the content of creatinine in the urine. Among patients with liver disease requires constant monitoring of the functions of this organ.
Powder for suspensions used for children up to three months. And how to take the suspension "Amoxiclav" - before or after meals? It should be used twice a day, with meals. Dosing is carried out using a special pipette. It is 30 mg of amoxicillin per kilogram of weight.
Knowing how Amoxiclav is prescribed to children - before meals or after meals, we add that for babies older than three months, 20 mg of the drug are used against the background of mild or moderate infections. For especially severe forms, 40 mg should be used.
The second dosage option is also used for the treatment of deep infections, such as inflammation of the middle ear, sinusitis, bronchitis, pneumonia, etc. The instruction is attached to this medicinal product, which contains special tables. They allow with the maximum accuracy to calculate the required baby dose.
So, the drug is taken with meals, which is confirmed by the instructions for "Amoxiclav". Before or after a meal, take it, you can also check with the doctor.
The maximum allowable daily dose of amoxicillin for children are 45 mg. For adults, the total dose should not exceed 6 grams. As for clavulanic acid, it can be administered no more than 600 mg per day if it is an adult patient. The maximum daily amount of this substance for children should not exceed 10 mg per kg of body weight.
In the form of a suspension
"Amoxiclav" (before a meal or after an antibiotic is prescribed, we have already found out) in the form of a powder for suspensions used to treat children. In 5 mg of the prepared suspension is 250 mg of amoxicillin. It also contains 62 mg of clavulanic acid.
To give the drug a pleasant taste, it includes sweet substances along with fruit flavors. Powder for suspensions is packaged in dark glass bottles. Their volume is 50 or 140 milliliters. In the box with the bottle put a spoon dispenser.
And now you don’t have to guess, before eating or after taking Amoxiclav to children, as the instruction advises doing it during meals.
In the form of tablets
This drug is released in the form of tablets that are coated. Tablets are white and oval. One 625-milligram tablet contains 500 mg of amoxicillin. It also contains 125 mg of potassium salt.
These tablets can be produced in plastic cans of fifteen pieces each, and, moreover, in aluminum blisters in the amount of five or seven pieces. 1000 mg tablets are also coated and have an oblong shape with beveled edges. They contain 875 milligrams of antibiotic. They also contain 120 mg of clavulanic acid.
Contraindications to the use of the drug
Of course, it is of great importance to give the child Amoxiclav suspension before or after eating. After all, when taking the presented drug may be a violation of the liver, and, in addition, cholestatic jaundice. This is possible in the event that previously this tool has already been applied and the patient has an increased sensitivity to its components or to all penicillins in general.
Patients with allergies to cephalosporins, and, moreover, suffering from pseudomembranous colitis or having problems with the functions of the liver, this drug is prescribed with great caution.
Among patients with mononucleosis or in the presence of lymphocytic leukemia, which was previously prescribed ampicillin, a rash of the type erythematous can be observed. In this situation, the antibiotic must be canceled. Drink before meals or after "Amoxiclav", of course, everyone decides for himself. But it is better to follow the recommendations of experts.
As a rule, these or other side effects are easily tolerated by patients and quickly pass. Side effects are most often observed among elderly patients, and, moreover, among those who have used Amoxiclav for a long time. Often, side effects occur during or immediately after treatment, but sometimes it happens that their development occurs several weeks after the end of the use of the medication:
- The digestive system usually reacts with diarrhea, nausea, vomiting, and dyspepsia. Less common is flatulence along with stomatitis, gastritis, discoloration of the tongue, glossitis and enterocolitis.
- Pseudomembranous colitis may appear during or after the completion of therapy with this drug.This disease is caused by one of the bacteria from the Clostridium family.
- The blood system responds to Amoxiclav with the development of anemia, including hemolytic, and the reaction also manifests itself in the form of eosinophilia, platelet reduction and agranulocytosis.
- As for the nervous system, here we can talk about headaches, dizziness, insomnia, convulsions, inappropriate behavior on the part of the patient or hyperactivity.
- As a result of taking this medication, liver sample values may increase along with serum bilirubin level.
- The skin can respond to Amoxiclav's onset of rash, urticaria, and angioedema. Less common is the development of erythema multiforme. The development of toxic epidermal necrolysis along with exfoliative dermatitis and Stevens-Johnson syndrome is not excluded.
- The urinary system reacts, as a rule, by the appearance of blood in the urine and interstitial nephritis. On the background of long-term use of the drug, fever may occur along with oral candidiasis. There is also a danger of developing candidal vaginitis.
Before eating or after suspension "Amoxiclav" take pregnant? The drug during pregnancy is better not to use. The exceptions are those situations in which its use is higher than the intended harm. Taking this drug during pregnancy increases the risk of colitis in newborns.
"Amoxiclav" in the treatment of angina
Antibiotics for the treatment of angina are prescribed only in situations where it manifests itself in moderate or excessively severe form. "Amoxiclav" as a penicillin antibiotic is often prescribed for tonsillitis. But its use is shown only in cases where the bacterial form of the disease is confirmed. It is extremely important to check the pathogenic microflora for sensitivity to this drug.
For the treatment of angina among children use suspensions, and tablets are prescribed for adults. In severe situations, use the drug injections. It should be borne in mind that regardless of the method of use of Amoksiklava (before or after a meal or during it, as the instructions suggest), it cannot be used for a long time, as this may increase the resistance of the pathogenic microflora in relation to the drug.
Compatibility with other drugs
It is extremely undesirable to use at the same time with drugs of indirect anticoagulants. This can cause an increase in the prothrombin period. The interaction of "Amoksiklava" and "Allopurinol" may cause the risk of exanthema. Amoxiclav is able to enhance the toxicity of Metatrexate. You also can not use the substances amoxicillin and rifampicin at the same time, as they are antagonists, and their combined use reduces the antibacterial effect of both.
It can not be prescribed in conjunction with tetracyclines or macrolides, since they are bacteriostatic antibiotics. It is also forbidden to use with sulfonamides, as this may cause a decrease in the effectiveness of the use of the presented drug. It is necessary to take into account the fact that the use of funds reduces to a large extent the effectiveness of contraceptives.
Now you know how to take - before meals or after - “Amoxiclav”, and are familiar with the peculiarities of its effects on the body.